Role of proteolysis in development of murine adipose tissue

Valerie Christiaens; Ilse Scroyen; H. Roger Lijnen

doi:10.1160/TH07-10-0589

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2008; 99(02): 290-294
DOI: 10.1160/TH07-10-0589

Theme Issue Article

Schattauer GmbH

Role of proteolysis in development of murine adipose tissue

Valerie Christiaens

¹Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium

,

Ilse Scroyen

¹Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium

,

H. Roger Lijnen

¹Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium

› Author Affiliations

Abstract

Summary

Obesity is a common disorder, and related diseases such as diabetes, atherosclerosis, hypertension, cardiovascular disease and cancer are a major cause of mortality and morbidity inWesterntype societies. Development of obesity is associated with extensive modifications in adipose tissue involving adipogenesis, angiogenesis and extracellular matrix proteolysis. The fibrinolytic (plasminogen/plasmin) and matrix metalloproteinase (MMP) systems cooperate in these processes. A nutritionally induced obesity model in transgenic mice has been used extensively to study the role of the fibrinolytic and MMP systems in the development of obesity. These studies support a role of both systems in adipogenesis and obesity, and suggest that modulation of proteolytic activity may affect development of adipose tissue.

Keywords

Animal models - fibrinolysis inhibitors - gene knock-out - matrix metalloproteinases - obesity

Full Text

References

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